Mar 19, 2015 · INTRODUCTION. Artesunate, clinical … Dec 1, 2020 · Artesunate was shown to markedly impede the growth of human breast cancer cell and nasopharyngeal cancer cell lines by inducing G1 cell cycle arrest. 01 Oct 13, 2015 · Abstract. May 5, 2022 · Artesunate (ART) (chemo-protective agent) is a water-soluble active derivative of Artemisia annua as compared to other derivatives, mainly used in treatment of malaria [5]. Feb 27, 2018 · König and colleagues evaluated the possibility of ototoxicity in breast cancer patients treated with artesunate plus ongoing oncological treatment for four weeks. Methods: The human breast tumor cell line MCF-7 was transplanted into nude mice, and the animals were treated with various doses of ART alone or in Nov 5, 2022 · Recent studies have found that ART also exhibits extensive antitumor effects in liver cancer [13–15], oral tongue squamous cell carcinoma , bladder cancer [17, 18], and breast cancer [19–21]. Feb 1, 2011 · The antimalarial agent artesunate (ART) activates programmed cell death (PCD) in cancer cells in a manner dependent on the presence of iron and the generation of reactive oxygen species. Feb 7, 2022 · Artesunate: Breast: Inducing G2/M cell cycle arrest through autophagy induction: Chen et al. Trolox, chloroquine, and holotransferrin were purchased from Sigma. The incidence of breast cancer is still on the rise worldwide (Ferlay et al. Hearing loss. Herein, we report on the compassionate use of ART in a patient with metastatic breast cancer. 128431 Corpus ID: 246419653; Potential of transpapillary route for artesunate-loaded microneedles against breast cancer cell line @article{Patil2022PotentialOT, title={Potential of transpapillary route for artesunate-loaded microneedles against breast cancer cell line}, author={Amar P. Artemisinins are sesquiterpene trioxanes ( Figure 1A) that have been clinically used to treat malaria ( Augustin et al. used in the traditional Chinese medicine, is being applied as a first-line drug for malaria treatment, and trials are ongoing that include this drug in cancer therapy. Exp Mol Pathol. Jan 3, 2024 · Triple-negative breast cancer (TNBC) is a difficult-to-treat, aggressive cancer type. 2022. , Ghoshal, A. Feb 15, 2019 · In 2018, Cornelia von Hagens et al. Center of Excellence. Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-sensitisation effects. 2. Dec 19, 2020 · The study mentioned that in 13 patients with metastatic breast cancer, up to 200 mg/day oral Artesunate add-on therapy (2. This suggested an increase of cleaved caspase-9/Bcl-2-HSP70 ratios might be involved in apoptosis induced by artesunate. Aug 8, 2017 · Raza, A. Patil and Bala Prabhakar and Pravin K Shende}, journal={Colloids and Surfaces A One of these medications is the antimalarial drug artesunate (ART) which also showed profound anticancer activity in vitro, in vivo, and in preliminary clinical pilot studies. Sep 10, 2021 · Artemisinin and its derivatives (AIDs) have recently been widely applied in cancer therapy as promising therapeutic agents owing to its hypotoxicity and special bioactivation pathways. Cancer Chemother Pharmacol. 1 mg/kg BW/day) in up to 37 treatment months did not result in any major safety concerns. Introduction. Along with anti-malarial activity, ART possesses a promising role in inhibiting the proliferation of cancer cells not only in in vitro and in vivo animal models, but also in humans (Meng et al. Artesunate was show to impede proliferation in colon, small cell lung cancer, leukaemia and glioma cell lines by inducing cell cycle arrest at G2/M phase ( Steinbrück, Pereira, & Efferth, 2010 ). 2014). Artesunate, the active agent from Artemisia annua L. Pretreated MDA-MB-231 metastatic cells were completely refractory to further artesunate treatment, whereas a similar treatment in MDA-MB-468, a non-metastatic cell line Aug 13, 2022 · Breast cancer is the leading cause of cancer-related deaths in women and remains a formidable therapeutic challenge. Sep 1, 2009 · Artesunate can induce apoptosis in breast cancer cells (T47D, MCF-7 and MDAMB231) and leukemia cells (J16, CEM and Molt4) through Fe dependent ROS generation along with cytochrome c dynamic locally advanced breast cancer: new audiological results from a prospective, open, uncontrolled, monocentric phase I study. Early-phase clinical trials testing oral [[16], [17], [18]] as well as intravenous [19] administration of artesunate to patients with late-stage solid tumor malignancies have demonstrated the safety of systemically administered artesunate in human cancer patients. The Maximum tolerated dose (MTD) for intravenous injection was 18 mg/kg. 36%) when compared to a PPC of 0. Systemic treatment of breast cancer is effective at the beginning of therapy. Two PtIV-artesunate anticancer prodrugs that target RAD51, a crucial protein in May 24, 2018 · Download Citation | Artesunate promotes G2/M cell cycle arrest in MCF7 breast cancer cells through ATM activation | Background Recent studies have revealed that artesunate (ART) has clear anti Development of Resistance towards Artesunate in MDA-MB-231 Human Breast Cancer Cells (PDF) Development of Resistance towards Artesunate in MDA-MB-231 Human Breast Cancer Cells | Thomas Efferth and B. The cells were harvested and treated with (FITC)-conjugated annexin V and propidium iodide (Annexin-V-FLUOS Staining kit from Roche Diagnostics (Mannheim, Germany) according to the recommendations Artesunate (ART) is a semi-synthetic derivative of artemisinin, the active principle of the Chinese herb Artemisia annua. Artesunate (ART) is a derivative of artemisinin that is extracted from the wormwood plant Artemisia annua. Oct 14, 2014 · Artesunate (ART) is an anti-malaria drug that has been shown to exhibit anti-tumor activity, and functional lysosomes are reported to be required for ART-induced cancer cell death, whereas the underlying molecular mechanisms remain largely elusive. Aug 4, 2023 · Konig M, von Hagens C, Hoth S, et al. The optimized ART-NLC demonstrated Dec 7, 2011 · Abstract. , 2015) and advanced stages are mostly regarded as being incurable. Jan 3, 2024 · Here, we show that the antimalarial ROS-generating compound artesunate (ART) exhibits higher cytotoxicity in epithelial than mesenchymal breast cancer cell lines. Abstract Artesunate-loaded nanostructured lipid carriers (ART-NLCs) were prepared by hot homogenization followed by ultrasonication technique. Dec 1, 2020 · The present study aims to evaluate the inhibitory effects of artesunate (a semi-synthetic derivative of artemisinin) on HSP70 and Bcl-2 expression in two breast cancer cell lines, 4T1 and MCF-7. None of these merited stopping the treatment. Mar 25, 2022 · The role of artesunate on the activation of AKT/Survivin signaling was analyzed by western blot and quantitative QPCR. It is well established in the literature that artesunate’s anti-malaria activity is linked to the induction of ROS within Plasmodium Jan 15, 2021 · Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells Anticancer Drugs , 25 ( 2014 ) , pp. Feb 1, 2018 · Li reported that artesunate inhibited the Wnt/beta-catenin signaling pathway in colon cancer cell lines and xenografts, decreasing tumor growth and spontaneous liver metastases . At this dose, adverse reactions were mild and self-limited . / Repurposing Artesunate for treatment of (Triple-negative) breast cancer – Breast cancer – Discussion Board May 12, 2017 · Metastatic Breast Cancer. While in short-term treatment of malaria, an excellent safety profile has been found for ART, the potential long-term treatment of cancer patients demands a phase I dose-finding clinical trial determining the daily ART dose which would be well Jul 12, 2011 · B) Human non-metastastc breast cancer cells MDA-MB-468 responded to artesunate treatment at various concentrations with a statistically significant decline in cell viability up to 50% (** P<0. (2020) Artesunate: Breast: Promoting G2/M cell cycle arrest in MCF7 cancer cells through Aug 27, 2021 · Breast cancer remains the leading cancer-related cause of the burden of disease among women, affecting 1 in 20 women globally and 1 in 8 women in high-income countries (94,95). Artemisinin and its derivatives have been the most useful drug for malarial treatment in human history. Ectopic expression of EMT-TF ZEB1 in epithelial or ZEB1 depletion in mesenchymal cells, respectively, reduced or increased ART-generated ROS levels, DNA damage and apoptotic cell death. In addition to pre-clinical evidence in a range of cancers Apr 16, 2015 · Introduction. edu We would like to show you a description here but the site won’t allow us. Jul 24, 2020 · Artesunate has proven for cytotoxic effects against ovarian, breast, colon, melanoma, leukemia, renal and prostate cancer cell culture [4,5,6,7, 103]. A biotin-guided platinumIV complex is highly cytotoxic against breast cancer cells but hypotoxic against mammary epithelial cells. Konig M, von Hagens C, Hoth S, Baumann I, Walter-Sack I, Edler L, Sertel S. reported that artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells . Artesunate is a semi-synthetic Breast cancer A 2017 trial examined results when 23 metastatic breast cancer patients received oral artesunate in addition to standard therapies for a 4 week period. (Cornelia von Hagens et al, Phytomedicine. In patients with Stage 4 Breast cancer, after 1 year the group that received no IV Vitamin C and IV Artesunate had a 74% survival rate. Population pharmacokinetics of artesunate and dihydroartemisinin during long-term oral administration of artesunate to patients with metastatic breast cancer. colsurfa. It possesses potent anti-inflammatory and immune-calming properties. The mono-biotinylated PtIV complex is superior to the Apr 1, 2020 · Artesunate has cytotoxic effect on human solid tumors. 1016/j. , metastasized breast cancer, cervical carcinoma, and non-small cell lung cancer (Table 1), all of which are difficult to manage by conventional chemotherapy. 3-4. Mitochondrial autophagy Jun 30, 2022 · A prospective phase 1 clinical trial in 23 breast cancer patients receiving 100-200mg oral artesunate for 4 weeks showed no dose-limiting audiotoxicity (Koenig 2016) The authors of a phase 1 trial (Deeken 2018) of intravenous artesunate in 19 patients with advanced solid tumors determined the maximum tolerated dose was 18mg/kg body weight per week. We have reported previously on the efficacy of a water-soluble, cationic organometallic compound (Ru Jan 11, 2016 · Artesunate-loaded nanostructured lipid carriers (ART-NLCs) were prepared by hot homogenization followed by ultrasonication technique and induced higher apoptosis rates in MCF-7 as well as MDA-MB-231cells than free ART. Dec 16, 2023 · Artesunate has anti-cancer activity in AML via cytochrome c. [2] Two PtIV–artesunate anticancer prodrugs that target RAD51, a crucial protein in homologous recombination mediating the sensitivity of cancer cells to DNA-damaging agents, were designed; their cytotoxicities against BRCA-proficient ovarian and breast cancer cells are significantly higher than those of cisplat Apr 17, 2024 · In breast cancer, ART increased EPHA8, EPHA10, EFNA2 and reduced EPHA3, EPHA7, and EFNA3 (Zadeh et al. [2] Sep 5, 2017 · A biotin-guided platinumIV complex is highly cytotoxic against breast cancer cells but hypotoxic against mammary epithelial cells and hence a promising drug candidate for the targeted therapy of breast cancer. Bachmeier - Academia. In malaria parasites, ART cytotoxicity originates from interactions with heme-derived iron within the food vacuole. 652 - 662 , 10. Our results demonstrate that in breast cancer cells ART exerts multifarious effects on protein, second messengers, and organelles involved in PCD signaling. However, after a variable period of time, progression occurs due to therapy resistance. Use is considered off-label or repurposed, as it does not have FDA approval for treating cancer. (2014) Artesunate: Breast: Down-regulating the expression of Bcl-2 and HSP70, Enhancing the expression of cleaved caspase-9 in MCF-7 and 4T1 cells: Pirali et al. Sep 30, 2008 · Ericsson T, Blank A, von Hagens C, Ashton M, Abelo A. Jan 1, 2022 · DOI: 10. 27) Ericsson T1, Blank A, von Hagens C, Ashton M, Äbelö A. Nov 22, 2011 · Recently, concerns have arisen after Baechmeier et al. , 2021 ). Keywords: Artesunate; Cell cycle; DNA damage response; MCF7 cell. 92 ± 1. This not only keeps the immune system balanced but may also oppose some triggers of cancer metastasis. 0000000000000089 View in Scopus Google Scholar Breast cancer is the most prevalent cancer diagnosis in women, with triple-negative and human epidermal growth factor 2 (HER2)-enriched advanced breast cancers having the poorest prognoses. artesunate (ART) exhibits higher cytotoxicity in epithelial than mesenchymal breast cancer cell lines. et al. 1, 2 Surgical resection has been regarded as the standard of care for gastric cancer, but the condition in the majority of patients was advanced or Mar 30, 2021 · This review provides a recent perspective of artesunate and other artemisinins as antimalarial drugs and their uses in cancer therapy. Evidence of disease stability was observed in 10 patients, with minor hemotologic effects in 3 patients, and minor hearing changes in 3, and vertigo in 1. In addition, ART stimulated the aggregation of LC3 Sep 10, 2021 · a Validation of PTK7 expression levels in different cancer cell lines by Western blots. Because there hasn't been much research on the use of artemisinin for treating cancer, there are lots of Artemisinin has also shown anti-cancer effects against prostate cancer, breast cancer, liver cancer, leukemia, and oral cancer. Jan 3, 2022 · It is therefore likely that artesunate can influence homeostasis to counter abnormal signaling in cells during disease conditions. The lipid negatively charged nanoemulsion was formulated by modified hot homogenization method then covered with positively charged chitosan via … Conclusions: ART can inhibit cell proliferation and promote G2/M arrest in MCF7 cells through ATM activation and the ensuing "ATM-Chk2-Cdc25C" pathway, thus implicating ART as a novel candidate for breast cancer chemotherapy. Jun 2016;77(6):1321. Investigation of ototoxicity of artesunate as add-on therapy in patients with metastatic or locally advanced breast cancer: new audiological results from a prospective, open, uncontrolled, monocentric phase I study. Oct 3, 2019 · Artesunate was most active against leukemia and colon cancer cell lines. Compared to the IV Vitamin C and IV Artesunate group which had a 90% survival rate after 1 year. Artesunate (ART), clinically used as anti-malarial agent, has recently revealed remarkable anti-tumor Breast cancer is by far the most frequent cancer among women, accounting for approximately 25 % of all new female cancers reported worldwide [14]. g. Apr 24, 2017 · Purpose The antimalarial drug artesunate (ART) is a promising candidate for cancer treatment as it displays anticancer effects in various models. The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells. These drugs require a prescription, can be Jan 3, 2024 · Here, we show that the antimalarial ROS-generating compound artesunate (ART) exhibits higher cytotoxicity in epithelial than mesenchymal breast cancer cell lines. Cabello et al. Artesunate (ART), a semi-synthetic derivative of artemisinin, is the active component of the Chinese herb Artemisin annual. Bachmeier, B. As only 50–70 % of patients with breast cancer receiving chemotherapy respond to first-line treatment, the need to discover new, effective chemotherapeutic alternatives is imperative [13]. Feb 25, 2011 · In the study presented here we sought to determine the contributions and connections of endolysosomes and mitochondria during ART-induced PCD in human breast cancer cells. However, it is not clear whether ART regulate the level of EFNA3 in CM. Jan 1, 2024 · Artesunate has been investigated in a panel of clinical phase 1 and 2 trials in various tumor types other than glioblastoma during the past years, e. The morbidity and mortality associated with advanced disease, as well as the emergence of multi-drug resistant variants, highlights the urgency to develop Artesunate was most active against leukemia and colon cancer cell lines. 4). May 9, 2024 · Artesunate, a drug approved for use in malaria, has been researched for use in cancer more than other artemisinins. Here, we show that artesunate Artesunate (ART), a derivative of the Chinese herb arte-misinin, is currently clinically used as a first-line drug for malaria therapy. However, challenges, such as poor solubility, high toxicity, and off-target accumulation, have limited its clinical use as a free ART in monotherapy Oct 16, 2018 · Two PtIV-artesunate anticancer prodrugs that target RAD51, a crucial protein in homologous recombination mediating the sensitivity of cancer cells to DNA-damaging agents, were designed; their cytotoxicities against BRCA-proficient ovarian and breast cancer cells are significantly higher than those of cisplatin. The artesunate has an advantage of a hydrophilic group over Mar 19, 2015 · Artesunate (ART), a derivative of artemisinin (the active principle of Artemisia annua; sweet wormwood), initially used in the anti-malarial combination therapy against multidrug-resistant falciparum and vivax malaria was later discovered by the National Cancer Institute (NCI, USA) to possess potent anti-proliferative and anti-angiogenic activity against cancer, especially against breast Jul 23, 2020 · The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells. Sep 27, 2017 · Therefore, in the present study, we investigated the mechanism by which artesunate induced cell death in human breast cancer MCF-7 cell line. Artesunate (ART)--a well-known hydrophobic anti-malarial agent was incorporated in a polymer-lipid hybrid nanocolloidal system for anti-cancer therapeutic. showed that a 24 h preincubation with 20 μM artesunate induces resistance in highly metastatic breast cancer cells. 2019; 107 :10–22. , Chockalingam, S. ART has now been analyzed for its anti-cancer activity against 55 cell lines of the Developmental Therapeutics Mar 30, 2021 · Greenshields et al. van der Kooy F, Sullivan SE. Sep 27, 2017 · Conclusions: According to our results, it could be concluded that artesunate could inhibit the growth of MCF-7 breast cancer cells through induction of apoptosis by intrinsic and extrinsic caspase-dependent pathways. Erratum to: Investigation of ototoxicity of artesunate as add-on therapy in patients with metastatic or locally advanced breast cancer: new audiological results from a prospective, open, uncontrolled, monocentric phase I study. ART upregulated the expression of Beclin1, an initiator of autophagy (type II programmed cell death). , 2019) Conclusion Dec 30, 2021 · One group of compounds that is currently being explored for drug repurposing is artemisinin (ARS) and its derivatives (henceforth referred to as artemisinins). ART reveals remarkable activity against otherwise multidrug-resistant Plasmodium falciparum and P. We observed significant changes in EPH/ephrin transcript levels after treating breast cancer cells with artesunate for 24 h. Artesunate was purchased from Saokim Ltd. ART has directly inhibited cell proliferation in multiple cancer types including neuroblastoma Feb 15, 2019 · Introduction. In our previous study, shown that the artesunate induced apoptosis by activation of caspase-9 in human breast cancer cell line MCF-7 in vitro [27]. 74 µg/mL (24. Therefore, we claim that artesunate could be introduced as a suitable candidate for the treatment of the breast cancer. EXPERIMENTAL PROCEDURES Reagents. Connexin-43 enhances tumor suppressing activity of artesunate via gap junction-dependent as well as independent pathways in human breast cancer cells. Artesunate (ART), a derivative of artemisinin (the active principle of Artemisia annua; sweet wormwood), initially used in the anti-malarial combination therapy against multidrug-resistant falciparum and vivax malaria was later discovered by the National Cancer Institute (NCI, USA) to possess potent anti-proliferative and anti-angiogenic activity against cancer, especially Jun 1, 2022 · Artesunate (AS), the first-line treatment of malaria with a satisfactory safety profile, has been repurposed as a potential anticancer candidate as it mainly generates reactive oxygen species (ROS) through its intrinsic endoperoxide bridge reacting with ferrous-based catalysts to suppress cancer cell growth. A 2017 trial examined results when 23 metastatic breast cancer patients received oral artesunate in addition to standard therapies for a 4 week period. b Flow cytometry assay of the binding of SAC, CSAC, sgc8c control and sgc8c (250 nM, Cy5-labeled sequences). ART is an antimalarial drug that has been shown to be safe and effective for clinical use. Dizziness. Breast cancer is the most common cancer and the second leading cause of cancer death in industrialized countries. Gastric cancer is a common malignant tumor in the digestive system, and the morbidity and mortality associated with this disease are ranked second highest of all malignant neoplasms in Eastern Asia, Eastern Europe, and South America. In addition to its antimalarial properties, ART has been attracting attention over recent years due to its reported inhibitory effects on cancer Jul 1, 2017 · Prospective open uncontrolled phase I study to define a well-tolerated dose of oral artesunate as add-on therapy in patients with metastatic breast cancer (ARTIC M33/2) Sep 27, 2017 · Conclusions: According to our results, it could be concluded that artesunate could inhibit the growth of MCF-7 breast cancer cells through induction of apoptosis by intrinsic and extrinsic caspase-dependent pathways. Finally, we used two mouse tumor models to investigate the function of artesunate on the in vivo growth of lung cancer cells. reported that dihydroartemisinin (DHA) could serve as redox chemotherapeutic by selectively targeting melanoma cells but not primary melanocytes with the induction of Feb 2, 2011 · The antimalarial agent artesunate (ART) activates programmed cell death (PCD) in cancer cells in a manner dependent on the presence of iron and the generation of reactive oxygen species. studied 13 patients with metastatic breast cancer and divided them into three groups by oral administration of artesunate with a dose of 100 mg/day, 150 mg/day, and 200 mg/day, respectively. Artesunate is an artemisinin derivative. Ringing in the ears. c Dec 1, 2020 · Because of its proposed importance in cancer, the HSP70 has become a popular target for drug discovery, efforts which have so far brought insignificant success. Recent studies have revealed that artesunate could efficiently delay the growth rate of leukemia (J-Jhan), colon carcinoma (HCT-116), small-cell lung carcinoma (H69) and glioma (U251) cancer cell Apr 25, 2023 · 2. This calls for a modern treatment based on tumor biology, the best evidence-based therapy available, and just as well for the inclusion of patients’ preferences (Cardoso et al. Lysosomes were identified as the primary target of ART, being converted to pro-death organelles through iron-catalyzed generation of ROS. In this study, we aimed to elucidate the molecular mechanisms underlying ART-induced cell death. The possible mechanism of action of artesunate in breast cancer cells was explored by focusing on its ability to induce apoptosis as well as activation of the key apoptosis enzymes, caspases. Artesunate Reduces Viability in HCT-116 and HT-29 Derived Cancer Spheroids. Preliminary or weak evidence shows that these drugs may lead to better cancer outcomes. Artemisinin and its derivatives have demonstrated multiple activities in the context of various cancers. In recent years, studies have suggested that it could be a good candidate for a novel chemotherapeu-tics [4, 5]. (A) TAM-R cells were seeded in six-well plates at a density of 3×10 4 –6×10 4 per well in Improved Minimum Essential Medium (IMEM) supplemented with 5% fetal bovine serum (FBS) and cultured for 4 days. Despite increasing interest in its therapeutic application, the mode of cell killing provoked by artesunate in human cells is unknown. Ectopic expression of EMT‑TF ZEB1 in epithelial or ZEB1 depletion in mesenchymal cells Dec 11, 2023 · A phase I clinical trial found that the apparent clearance rate increased with time after artesunate use in patients with breast cancer . Konkimalla found that downregulating the Ras-Raf-MEK-ERK pathway is a key mechanism of artesunate’s activity in cancer cell lines . Artemisinin is extracted from the plant Artemisia annua. Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells. As a single agent, ART moderately affected the viability of HCT-116 spheroids in a dose-dependent manner (Figure 2 A), as ART treatment with a peak plasma concentration (PPC) of 15 µg/mL resulted in a significantly higher decrease in viable cells (35. Our previous studies have proved that ART inhibits the tumorigenesis of CM, so we speculated ART plays a role in inhibiting CM prognosis by regulating EFNA3. In all cases, artesunate was May 26, 2011 · The breast cancer cell lines MDA-MB-231 and MDA-MB-468 were grown in 24-well plates and incubated with Artesunate as described in the result section. Apr 7, 2024 · Triple negative breast cancer (TNBC) represents a subtype of breast cancer that does not express the three major prognostic receptors of human epidermal growth factor receptor 2 (HER2), progesterone (PR), and estrogen (ER). This limits treatment options and results in a high rate of mortality. vivax malaria. Non-small cell lung cancer cell lines showed the highest mean GI50 value, indicating the lowest sensitivity toward artesunate in this test panel. Aug 7, 2013 · We found that artesunate (ART) inhibited the growth of MCF-7 and MDA-MB-231 breast cancer cells. ART arrested the cell cycle in the G2/M phase, which was accompanied by an upregulation of p21. , 2017, WMA 2017). Systemic treatment (chemotherapy and endocrine therapy) of breast cancer is initially effective; however, after a period of time, drug resistance typically develops . Apr 15, 2011 · Abstract. Mitochondria participate in a myriad of essential cellular processes, such as metabolism, and are becoming an ideal target for cancer therapy. 2022). 45 ± Dec 1, 2020 · In breast cancer cells administration of artesunate increased the band intensity of 37 kDa protein (cleaved caspase-9) at a concentration of 30 μM, when compared to control (Fig. 1097/cad. Intermediate GI50 values also were obtained for melanomas, breast, ovarian, prostate, CNS, and renal cancer cell lines. , 2020; Wang et al. Interested in receiving weekly updates about the Metastatic Breast Cancer Center of Excellence? Subscribe Now! Tumor Apr 7, 2014 · Purpose: The objective of this study was to investigate the anti-tumor effects and analyze the mechanism of artesunate (ART) action on breast cancer in vivo using tumor transplanted nude mice. In addition to its antimalarial properties, ART has been attracting attention over recent years due to its reported inhibitory effects on cancer Jul 1, 2017 · Prospective open uncontrolled phase I study to define a well-tolerated dose of oral artesunate as add-on therapy in patients with metastatic breast cancer (ARTIC M33/2) Mar 19, 2015 · Furthermore, ART can inhibit breast cancer MCF-7 cell proliferation and promote G 2 /M arrest by activating the ataxia-telangiectasia mutated/checkpoint kinase 2/cell division cycle 25 (CDC25) C Jan 21, 2016 · Other clinical trials showed that artesunate was safe and well-tolerated in patients with breast cancer (76, 77), while artemisinin treatment in pregnant women did not elevate the risk of . Jun 9, 2022 · Possible side effects include: Skin rash. Artemisinin also increases bile flow helping Apr 4, 2019 · Effect of artesunate (ART) (4 days) on tamoxifen-resistant breast cancer cells (TAM-R) cell growth. Out of 23 patients in the study, four patients exhibited vertigo. Artesunate treatment caused significant growth inhibition and apoptosis in A549 cells. ART also shows potent anti-proliferative and anti-angiogenic activity against cancer, particularly against breast cancer, colon cancer and leukemia [6]. 1. me lz qy dw hd rw qn kd ia iz